Microprobes for Life Science
support@microprobes.com +1 301 330 9788
At Microprobes for Life Science, we have the privilege of assisting hundreds of investigators worldwide in the design and selection of the most appropriate probes for their research. From learning about the scope and goals of each experiment, anticipating the challenges ahead, and celebrating great results, our engineers are with you every step of the way. To tell the stories of some of these projects, we will be sharing a series of case studies to both highlight the work of these researchers and to inspire others with new study paradigms. We consider this an important part of our Research2Research initiative, which strives to link new investigators with our own experts as well as the expertise of other researchers.
Research to Research
Research to Research
This case study features a particularly challenging application: Single-unit multichannel recording from closely spaced brain structures in a freely-behaving mouse, using a chronically implanted probe. This case presented a unique combination of requirements:
  • Simultaneous single unit and LFP recordings from multiple ipsilateral cortical areas with greatly differing depths.
  • A connector mounted on the far caudal end of the skull, to allow for head-forward tethered and telemetric recordings in freely-behaving animals.
  • Far-chronic implant longevity, greater than three months.
William Lee
William Li Massachusetts General Hospital, Ziv Williams Lab
qoute
Is there any chance we can design a 16 channel FMA that spans 4x1mm that has 8 shorter electrodes on one end and 8 longer electrodes on another end? There would be a 2mm or so gap between the two 8 electrode bundles. We are trying to target two cortical regions in mice simultaneously. Let me know if this is possible.
Microprobes team
Our team
Hi William,

We can very likely do something just like this, though I think the main question is whether we can do so using our existing FMA substrate layout or if it will require a custom template as it sounds like the electrode placement may need to be very precise to hit your particular targets simultaneously.

The cable can be located anywhere... it can be at either the long or short orientation and on either side. Just let us know what would work best and we will put together a design to meet it!
Visualizing the design
Each color a different electrode length
Each color a different electrode length
Custom location of the cable between the array and the connector
Custom location of the cable between the array and the connector
Final product based on the researcher's specs
Final product for MGH, at Ziv Williams Lab .
check Customize the length, impedance and location of each of the electrodes of your FMA
check Customize the cable location of any of the sides of the ceramic substrate.
check Achieve 7+ years of single unit recording.
check Ideal from large animals NHP to small rodents.
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