Opto MEA

Opto MEA

Introduction

With our novel and reliable products the photoactivation/photoinhibition of cells through an integrated optical fiber combined with multichannel arrays allow you to achieve neural electrophysiological recording of an extended brain area in parallel with photostimulation.

User Specify

  • Multiple optical fiber diameter available.
  • Up to 32 penetrating electrodes surrounding one or more optical fiber.
  • Custom length of each electrode and optical fibers between 1 to 40 mm, including different lengths within the array.
  • Custom spacing between electrodes is in the range of 0.1 - 1 mm
  • Custom microelectrode impedance for individual electrodes ranges between 10 kΩ - 5 MΩ.
  • Custom electrode tip diameter between 1 - 6 µm.
  • Custom reference and ground electrodes according to the researcher’s requirements.
  • Optionally integrated fiber optic and/or drug delivery cannula.
  • Parylene-C electrode insulation.
  • Pure Iridium is suggested for chronic stimulation studies.
  • Optional polyimide tubing for additional stiffness.

Metal Type

Pt-Ir
Platinum
Iridium
Ir
Pure
Iridium

Applications

Single Unit - LFP Ecog
Spinal Cord
Isolated Preparations

Subjects

Rodent
Rodent
Larger Animals
LARGER ANIMALS
Bird
Bird
Non-Human Primates
NHP

The fiber optic is positioned in the middle of the array, its vertical position is custom and its receptacle is compatible with most of the light sources.

The small-scale but high-density arrays provide multichannel Single-Unit (SUA), Multi-Unit (MUA) and Field Potential (FP) data leading to consistent and high-quality results.

Standard Layouts

Layout I. (Top view)
Layout I. (Top view)
Layout II. (Top view)
Layout II. (Top view)
Layout II. (Top view)
Layout II. (Top view)
Layout IV. (Top view)
Layout IV. (Top view)
  • Electrode diameter 75 µm, 125 µm and 225 µm
  • A. Distance between electrodes 100 µm to 1 mm
  • B. Distance between electrode to fiber optic 100 µm to 1 mm
  • C. Fiber Optic diameter 125 µm or 230 µm
Optogenetics combines genetic targeting of specific neurons

Optogenetics combines genetic targeting of specific neurons or proteins with optical technology for imaging or control of the targets within intact, living neural circuits (Deisseroth et al., Next-generation optical technologies for illuminating genetically targeted brain circuits. J Neurosci. 2006 Oct 11;26(41):10380-6.)

Data provided by IIka Diester

Data provided by IIka Diester, Sensory-motor circuits and Optogenetics, Ernst Struengmann Institute in Cooperation with Max Planck Society - Germany

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