Opto MWA

Opto MWA

Introduction

With our novel and reliable products the photoactivation/photoinhibition of cells through an integrated optical fiber, multichannel electrophysiological recording and/or stimulation of an extended brain area can be achieved in parallel.

Designed for chronic experiments, the Microprobes Optogenetics Microwire Array  Opto-MWA  provides the optimum in flexibility and affordable alternative for the neuroscience community.

User Specify

  • Multiple optical fiber diameter available.
  • Up to 32 penetrating wires per array for short- and long-term recording.
  • Custom wire length (5-23 mm), including different length for each row.
  • Custom spacing between electrodes is in the range of 0.1 - 1 mm
  • Custom spacing between wires is in the range of 250 - 1000 µm.
  • Custom wire diameter options available (25/ 50 µm).
  • Impedance options between 200-800 kΩ.
  • Stainless Steel and Platinum/Iridium fine wires teflon or polyimide insulation material.
  • Custom reference and ground electrode according to the researcher's requeriments.

Metal Type

Pt-Ir
Platinum
Iridium
SS
Stainless
Steel

Applications

Single Unit - LFP Ecog
Spinal Cord
Isolated Preparations

Subjects

Rodent
Rodent
Larger Animals
LARGER ANIMALS
Bird
Bird
Non-Human Primates
NHP

The fiber optic is positioned in the middle of the array, its vertical position is custom and its receptacle is compatible with most of the light sources.

The small-scale but high-density arrays provide multichannel Single-Unit (SUA), Multi-Unit (MUA) and Field Potential (FP) data leading to consistent and high-quality results.

The small-scale but high-density arrays provide multichannel Single-Unit (SUA), Multi-Unit (MUA) and Field Potential (FP) data leading to consistent and high-quality results.

Standard Layouts

Layout I. (Top view)
Layout I. (Top view)
Layout II. (Top view)
Layout II. (Top view)
Layout II. (Top view)
Layout II. (Top view)
Layout IV. (Top view)
Layout IV. (Top view)
  • Wire diameter 25 µm and 50 µm
  • A. Distance between wires 100 µm to 1 mm
  • B. Distance between wire to fiber optic 100 µm to 1 mm
  • C. Fiber Optic diameter 125 µm or 230 µm
Optogenetics combines genetic targeting of specific neurons

Optogenetics combines genetic targeting of specific neurons or proteins with optical technology for imaging or control of the targets within intact, living neural circuits (Deisseroth et al., Next-generation optical technologies for illuminating genetically targeted brain circuits. J Neurosci. 2006 Oct 11;26(41):10380-6.)

Data provided by IIka Diester, Sensory-motor circuits and Optogenetics, Ernst Struengmann Institute in Cooperation with Max Planck Society - Germany

Recording of an optically stimulated neuron

Recording of an optically stimulated neuron expressing channel rhodopsin (CHR2) in the striatum of a mouse using a custom Opto Micro-Wire array (Microprobes - Gaithersburg, MD). A. RASTER and PETH of striatal spikes generated using 1ms pulses of 473nm blue laser light. B. Waveforms of spikes from A, plotted in relation to the onset and offset of the laser pulse. C. Spike fidelity is linearly correlated to laser output intensity.

Courtesy of Mark O. West’s Lab at Rutgers University - www.rci.rutgers.edu/~markwest

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